Article

Targeting LSD1 inhibits gastric cancer by reprogramming macrophages and restoring T-cell response

2026-07-01

Abstract excerpt

<title>Abstract</title> <p> The heightened expression of lysine-specific demethylase 1 (LSD1/KDM1A) in multiple malignancies facilitates immune evasion, aiding in tumor survival; however, its role in shaping the gastric cancer (GC) tumor immune microenvironment remains incompletely defined. Here, we show that loss of tumor cell-intrinsic LSD1 skews M0 macrophage polarization into an anti-tumor M1 phenotype, enha...

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Literature Corpus work: 8c03e747-c483-5b94-8343-40ff22b7584e
DOI: 10.21203/rs.3.rs-10063093/v1

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