Article

Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer

2021-07-12

Abstract excerpt

Aberrations in nuclear size and shape are commonly used to identify cancerous tissue. However, it remains unclear whether the disturbed nuclear structure directly contributes to the cancer pathology or is merely a consequence of other events occurring during tumorigenesis. Here, we show that highly invasive and proliferative breast cancer cells frequently exhibit Akt-driven lower expression of the nuclear envelope...

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Identifiers and source

Literature Corpus work: eb8b7a26-1195-5c06-97ee-6fe3ecc83738
DOI: 10.1101/2021.07.12.451842

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