Article

LAP1 supports nuclear plasticity during constrained migration

2021-06-23

Abstract excerpt

<h4>ABSTRACT</h4> Metastasis involves dissemination of cancer cells away from a primary tumour and colonisation at distal sites. During this process, cancer cells must negotiate multiple physical constraints imposed by the microenvironment and tissue structure. The biophysical properties of the nucleus must be tuned since they pose a challenge to constrained migration. By analysing nuclear genes upregulated durin...

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Literature Corpus work: 260fc09a-1cd8-5b02-8b3d-0360bc6483fe
DOI: 10.1101/2021.06.23.449503

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