Emerin deficiency drives MCF7 cells to an invasive phenotype

Abstract excerpt

During metastasis, cancer cells traverse the vasculature by squeezing through very small gaps in the endothelium. Thus, nuclei in metastatic cancer cells must become more malleable to move through these gaps. Our lab showed invasive breast cancer cells have 50% less emerin protein resulting in smaller, misshapen nuclei, and higher metastasis rates than non-cancerous controls. Thus, emerin deficiency was predicted...

Topics

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• Breast Neoplasms
• Cell Movement
• Cell Nucleus
• Gene Expression Regulation, Neoplastic
• Gene Knockdown Techniques
• MCF-7 Cells
• Neoplasm Invasiveness
• Nuclear Proteins

Identifiers and source

Literature Corpus work

832bed70-0c48-5d1a-af86-1422555bf58a

DOI

10.1101/2024.02.21.581379