Article
Using tumour phylogenetics to identify the roots of metastasis in humans.
Nature reviews. Clinical oncology - 1 May 2015
Naxerova Kamila, Jain Rakesh K
Abstract excerpt
In cancer, much uncertainty remains regarding the origins of metastatic disease. Models of metastatic progression offer competing views on when dissemination occurs (at an early or late stage of tumour development), whether metastases at different sites arise independently and directly from the primary tumour or give rise to each other, and whether dynamic cell exchange occurs between synchronously growing...
Topics
- Disease Progression
- Epigenomics
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Microsatellite Repeats
- Models, Biological
- Neoplasm Metastasis
- Neoplasms
- Neoplastic Cells, Circulating
- Phylogeny