Article

Inferring cancer type-specific patterns of metastatic spread using Metient

2024-07-10

Abstract excerpt

Cancers differ in how they establish metastases. These differences can be studied by reconstructing the metastatic spread of a cancer from sequencing data of multiple tumors. Current methods to do so are limited by computational scalability and rely on technical assumptions that do not reflect current clinical knowledge. Metient overcomes these limitations using gradient-based, multi-objective optimization to gene...

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Literature Corpus work: 7bd8e403-58c4-5f5d-a6ec-165896e5e3d9
DOI: 10.1101/2024.07.09.602790

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