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INSR as a Potential Target of Bisphenol F-Induced Type 2 Diabetes: Causal Inference and Mechanistic Elucidation via Mendelian Randomization, Multi-Omics Integration, Single-Cell Transcriptomics, and Molecular Docking

2026-03-25

Abstract excerpt

<title>Abstract</title> <p>Background Bisphenol F (BPF), a widely adopted substitute for bisphenol A, is a suspected endocrine-disrupting chemical; however, its causal relationship with type 2 diabetes mellitus (T2D) and the underlying molecular mechanisms remain inadequately characterized. Methods Two-sample Mendelian randomization (MR) using European GWAS data evaluated the causal effect of BPF exposure on T2...

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Literature Corpus work
eb867561-6ab3-5968-a76c-14401c9f7bd6
DOI
10.21203/rs.3.rs-9201479/v1
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