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INSR as a Potential Target of Bisphenol F-Induced Type 2 Diabetes: Causal Inference and Mechanistic Elucidation via Mendelian Randomization, Multi-Omics Integration, Single-Cell Transcriptomics, and Molecular Dockin

2026-03-24

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Bisphenol F (BPF), a widely adopted substitute for bisphenol A, is a suspected endocrine-disrupting chemical; however, its causal relationship with type 2 diabetes mellitus (T2D) and the underlying molecular mechanisms remain inadequately characterized. <bold>Methods</bold> Two-sample Mendelian randomization (MR) using European GWAS data evaluated the causal...

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Literature Corpus work
c2a8201e-d09c-5a62-9a19-ad990422b0d5
DOI
10.21203/rs.3.rs-9191900/v1
Open publication

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INSR as a Potential Target of Bisphenol F-Induced Type 2 Diabetes: Causal Inference and Mechanistic Elucidation via Mendelian Randomization, Multi-Omics Integration, Single-Cell Transcriptomics, and Molecular DockinDOI 10.21203/rs.3.rs-9191900/v1
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