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Integrative transcriptomics and molecular simulations identify IRS1 and PRKCQ as translational biomarkers for EDC-associated PCOS risk stratification

2026-04-29

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<title>Abstract</title> <p>Background Endocrine-disrupting chemicals (EDCs) are linked to polycystic ovary syndrome (PCOS), but their transcriptional mechanisms remain unclear. Methods Microarray datasets were analyzed to identify DEGs, with GSE10946 as the training cohort and the merged external datasets GSE106724, GSE34526, and GSE98595 as the validation cohort. EDC-related targets were intersected with DEGs...

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Literature Corpus work
96e58236-ebdc-54a8-baef-2f70d28d9cb7
DOI
10.21203/rs.3.rs-9227802/v1
Open publication

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Integrative transcriptomics and molecular simulations identify IRS1 and PRKCQ as translational biomarkers for EDC-associated PCOS risk stratificationDOI 10.21203/rs.3.rs-9227802/v1
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