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Article

Integrative multi-omics analysis of druggable genes for therapeutic target identification in polycystic ovary syndrome.

Journal of ovarian research - 12 Dec 2025

Xu Dan, Jia Dan, Fang Xiaohui, Chen Wansu, Liu Ying, Song Qingxia, Song Xiudao

Abstract excerpt

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorders in women of reproductive age with limited targeted therapies. This study aimed to identify and prioritize potential druggable genes for PCOS through a purely computational, multi-omics approach. METHOD: We conducted an integrated in silico analysis leveraging publicly available datasets. A multi-omics Mendelian randomization (MR)...

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Source

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Identifiers

PMID: 41388545
DOI: 10.1186/s13048-025-01889-8
PMCID: PMC12699805

Genes

CBLN3
NRBP1
GHRL
CD4
IPP
TFRC
VIPR1

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