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Integrative multi-omics analysis of druggable genes for therapeutic target identification in polycystic ovary syndrome.

Journal of ovarian research - 12 Dec 2025

Xu Dan, Jia Dan, Fang Xiaohui, Chen Wansu, Liu Ying, Song Qingxia, Song Xiudao

Abstract excerpt

BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorders in women of reproductive age with limited targeted therapies. This study aimed to identify and prioritize potential druggable genes for PCOS through a purely computational, multi-omics approach. METHOD: We conducted an integrated in silico analysis leveraging publicly available datasets. A multi-omics Mendelian randomization (MR)...

Topics

Female
Polycystic Ovary Syndrome
Humans
Multiomics
Quantitative Trait Loci
Genetic Predisposition to Disease
Molecular Docking Simulation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41388545
DOI: 10.1186/s13048-025-01889-8
PMCID: PMC12699805

Genes

CBLN3
NRBP1
GHRL
CD4
IPP
TFRC
VIPR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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