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Article

Identifying novel proteins underlying bipolar disorder via integrating pQTLs of the plasma, CSF, and brain with GWAS summary data.

Translational psychiatry - 27 Aug 2024

Xiao Zhehao, Zheng Nan, Chen Haodong, Yang Zhelun, Wang Rui, Liang Zeyan

Abstract excerpt

Bipolar disorder (BD) presents a significant challenge due to its chronic and relapsing nature, with its underlying pathogenesis remaining elusive. This study employs Mendelian randomization (MR), a widely recognized genetic approach, to unveil intricate causal associations between proteins and BD, leveraging protein quantitative trait loci (pQTL) as key exposures. We integrate pQTL data from brain, cerebrospinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39191728
DOI: 10.1038/s41398-024-03056-x
PMCID: PMC11349952

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