Article

STAT1 Promotes PD-L1 Activation and Tumor Growth in Lymphangioleiomyomatosis

2024-12-12

Abstract excerpt

<h4>ABSTRACT</h4> Lymphangioleiomyomatosis (LAM) is a cystic lung disease that primarily affects women. LAM is caused by the invasion of metastatic smooth muscle-like cells into the lung parenchyma, leading to abnormal cell proliferation, lung remodeling and progressive respiratory failure. LAM cells have TSC gene mutations, which occur sporadically or in people with Tuberous Sclerosis Complex. Although it is kno...

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Literature Corpus work: 39def99b-7666-5aa2-9314-8cc5ac9d13a8
DOI: 10.1101/2024.12.11.627871

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