Article

Targeting the PI5P4K lipid kinase family in cancer using novel covalent inhibitors

2019-10-25

Abstract excerpt

<h4>Summary</h4> The PI5P4Ks have been demonstrated to be important for cancer cell proliferation and other diseases. However, the therapeutic potential of targeting these kinases is understudied due to a lack of potent, specific small molecules available. Here we present the discovery and characterization of a novel pan-PI5P4K inhibitor, THZ-P1-2, that covalently targets cysteines on a disordered loop in PI5P4Kα...

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Literature Corpus work: d9487f60-04df-53e3-8a6b-8a62f00dc98f
DOI: 10.1101/819961

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