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Article

A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells.

Biochimica et biophysica acta. Molecular basis of disease - 1 Feb 2023

Prawiro Christy, Bunney Tom D, Kampyli Charis, Yaguchi Hiroko, Katan Matilda, Bangham Charles R M

Abstract excerpt

BACKGROUND: Development of adult T-cell leukemia/lymphoma (ATL) involves human T-cell leukemia virus type 1 (HTLV-1) infection and accumulation of somatic mutations. The most frequently mutated gene in ATL (36 % of cases) is phospholipase C gamma1 (PLCG1). PLCG1 is also frequently mutated in other T-cell lymphomas. However, the functional consequences of the PLCG1 mutations in cancer cells have not been...

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Identifiers

PMID: 36442790
DOI: 10.1016/j.bbadis.2022.166601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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