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Article

LCK at the crossroad of immunodeficiency and autoimmunity: Mechanisms and therapeutic opportunities.

Immunology letters - 1 Jun 2026

Woessner Nadine M, Keller Baerbel, Minguet Susana

Abstract excerpt

The lymphocyte-specific protein tyrosine kinase (LCK) is the principal initiator of T cell receptor (TCR) signaling and a critical regulator of T-cell development, activation, and immune tolerance. Its critical expression in T cells positions LCK as both a molecular gatekeeper of adaptive immunity and an attractive therapeutic target. Loss-of-function mutations in LCK result in combined immunodeficiency with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41482192
DOI: 10.1016/j.imlet.2025.107126

Genes

LCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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LCK at the crossroad of immunodeficiency and autoimmunity: Mechanisms and therapeutic opportunities.PMID 41482192Read ↗

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