Article

Pathogenic mutations of human phosphorylation sites affect protein-protein interactions

2023-08-03

Abstract excerpt

Despite their lack of a defined 3D structure, intrinsically disordered regions (IDRs) of proteins play important biological roles. Many IDRs contain short linear motifs (SLiMs) that mediate protein-protein interactions (PPIs), which can be regulated by post-translational modifications like phosphorylation. 20% of pathogenic missense mutations are found in IDRs, and understanding how such mutations affect PPIs is e...

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Literature Corpus work: 704e6122-a0ec-5ef3-a307-1601052ee84c
DOI: 10.1101/2023.08.01.551433

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