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Thrombospondin-1 promotes liver fibrosis by enhancing TGF-β action in hepatic stellate cells

2023-10-16

Abstract excerpt

Insulin resistance in adipose tissue is thought to be a key contributor to the pathogenesis of various metabolic disorders including metabolic dysfunction-associated steatotic liver disease /metabolic dysfunction-associated steatohepatitis (MASLD/MASH), but the mechanism underlying this contribution to MASLD/MASH has remained unknown. We previously showed that dysregulation of the PDK1-FoxO1 signaling axis in adip...

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Literature Corpus work
eb6b01ee-c172-524e-ad58-28153174906c
DOI
10.21203/rs.3.rs-3430566/v1
Open publication

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Thrombospondin-1 promotes liver fibrosis by enhancing TGF-β action in hepatic stellate cellsDOI 10.21203/rs.3.rs-3430566/v1
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