Article

ASK1 overexpression protects from HFD-induced body weight gain via FGF21

2025-01-26

Abstract excerpt

People with obesity are at high risk to develop metabolic complications such as type 2 diabetes and metabolic dysfunction-associated fatty liver disease (MAFLD). We previously reported that the apoptosis signal-regulating kinase 1 (ASK1) regulates the development of MAFLD, since high fat diet (HFD)-fed mice with liver-specific ASK1 depletion and overexpression revealed increased and blunted development of MAFLD, r...

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Literature Corpus work: 21a237de-7840-5fd8-89cd-7e562d0cbe0a
DOI: 10.1101/2025.01.23.634369

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