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Article

TGF-β1-dependent expression of FOXS1 attenuates adipogenic potential and enhances a myofibroblast cellular phenotype.

The Journal of biological chemistry - 1 Sept 2025

Tavares Alexander H, Connelly Scott P, Maksat Daryn, Zheng Jane, Rabhi Nabil, Layne Matthew D

Abstract excerpt

White adipose tissue (WAT) fibrosis is a major determinant of obesity-induced cardiometabolic dysfunction and is characterized by excessive extracellular matrix deposition and myofibroblast activation. Transforming growth factor (TGF)-β1 is a profibrotic cytokine that potently induces myofibroblast activation in adipocyte stem cells (ASCs). How TGF-β1 orchestrates ASC activation in WAT fibrosis is not completely...

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Topics

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Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40774386
DOI: 10.1016/j.jbc.2025.110563
PMCID: PMC12423405

Genes

FOXS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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