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Thrombospondin 2 is a key determinant of fibrogenesis in non‐alcoholic fatty liver disease

27 Nov 2023

Abstract excerpt

OBJECTIVE: Hepatic overexpression of the thrombospondin 2 gene (THBS2) and elevated levels of circulating thrombospondin 2 (TSP2) have been observed in patients with chronic liver disease. This study aimed to identify the specific cells expressing THBS2/TSP2 in non-alcoholic fatty liver disease (NAFLD) and investigate the underlying mechanism behind THBS2/TSP2 upregulation. DESIGN: Comprehensive NAFLD liver gene...

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PMID: 38010940
DOI: 10.1111/liv.15792

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