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Transforming growth factor beta 1 (TGFβ1) plasmatic levels and haplotype structures in obesity: a role for TGFβ1 in steatosis development.

Molecular biology reports - 1 Sept 2021

Felicidade Ingrid, Bocchi Mayara, Ramos Marília Rizzon Zaparolli, Carlos Ligia de Oliveira, Wagner Nathalia Ramori Farinha, Campos Antônio Carlos Ligocki, Ribeiro Lúcia Regina, Mantovani Mário Sérgio, Watanabe Maria Angelica Ehara, Vitiello Glauco Akelinghton Freire

Abstract excerpt

BACKGROUND: Obesity is considered a chronic inflammatory disease and transforming growth factor beta 1 (TGFβ1) might exert important roles in disease pathogenesis regulating adipocyte differentiation and immune-inflammatory environment. However, the role of this cytokine as a biomarker in obesity is poorly addressed. Therefore, the present study aimed to evaluate the impact of TGFB1 polymorphisms and TGFβ1...

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PMID: 34403036
DOI: 10.1007/s11033-021-06640-2

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