Article

Genome-Wide Screens Identify Core Regulators of Cell Surface Prion Protein Expression

2025-12-09

Abstract excerpt

<h4>ABSTRACT</h4> Expression of the cellular prion protein, PrP C , on the surface of neurons plays an important role in the pathogenesis of prion disease. We performed genome-wide CRISPR/Cas9 knockout screens in prion-infectible cells of neuronal origin (CAD5) to identify regulators of cell surface PrP C expression. We identified and validated 46 positive and 21 negative regulators of cell surface PrP C expre...

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Literature Corpus work: eb55613a-c444-53cf-93c1-5abf78724663
DOI: 10.64898/2025.12.07.692843

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