Article

Dimeric prion protein ligand activates Adgrg6 but does not rescue myelinopathy of PrP-deficient mice

2020-07-07

Abstract excerpt

The adhesion G-protein coupled receptor Adgrg6 (formerly Gpr126) is instrumental in the development, maintenance and repair of peripheral nervous system myelin. The prion protein (PrP) is a potent activator of Adgrg6 and could be used as a potential therapeutic agent in treating peripheral demyelinating and dysmyelinating diseases. We designed a dimeric Fc-fusion protein comprising the myelinotrophic domain of PrP...

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Literature Corpus work: ed536f3d-d534-5de5-945d-4308583acf6a
DOI: 10.1101/2020.07.07.191452

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Dimeric prion protein ligand activates Adgrg6 but does not rescue myelinopathy of PrP-deficient miceDOI 10.1101/2020.07.07.191452Read

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