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Article

Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease.

The Biochemical journal - 28 Feb 2020

Thackray Alana M, Lam Brian, Shahira Binti Ab Razak Anisa, Yeo Giles, Bujdoso Raymond

Abstract excerpt

Prion diseases are fatal transmissible neurodegenerative conditions of humans and animals that arise through neurotoxicity induced by PrP misfolding. The cellular and molecular mechanisms of prion-induced neurotoxicity remain undefined. Understanding these processes will underpin therapeutic and control strategies for human and animal prion diseases, respectively. Prion diseases are difficult to study in their...

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Identifiers

PMID: 32108870
DOI: 10.1042/BCJ20190872
PMCID: PMC7054746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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