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Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells

12 Feb 2019

Abstract excerpt

Chimeric antigen receptor (CAR) technology can be used to engineer the antigen specificity of regulatory T cells (Tregs) and improve their potency as an adoptive cell therapy in multiple disease models. As synthetic receptors, CARs carry the risk of immunogenicity, particularly when derived from nonhuman antibodies. Using an HLA-A*02:01-specific CAR (A2-CAR) encoding a single-chain variable fragment (Fv) derived...

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PMID: 30753169
DOI: 10.1172/jci.insight.123672

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