Article

Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibility

2024-09-25

Abstract excerpt

<h4>Abstract Figure</h4> Graphical Abstract <h4>Highlights</h4> SOD2 knockdown and recovery is achieved in skeletal muscle by using a shRNA targeted to SOD2 mRNA controlled by a tetracycline Response Element and reverse tetracycline transactivator protein SOD2 KD is induced by administering doxycycline in the drinking water Mitochondrial functional decline and recovery follows the time course of SOD2 protein dec...

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Literature Corpus work: eb46559b-6484-5089-8d3b-045434e7483b
DOI: 10.1101/2024.09.23.614547

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Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibilityDOI 10.1101/2024.09.23.614547Read

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