Article
Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.
American journal of physiology. Cell physiology - 1 Dec 2009
Lustgarten Michael S, Jang Youngmok C, Liu Yuhong, Muller Florian L, Qi Wenbo, Steinhelper Mark, Brooks Susan V, Larkin Lisa, Shimizu Takahiko, Shirasawa Takuji, McManus Linda M, Bhattacharya Arunabh, Richardson Arlan, Van Remmen Holly
Abstract excerpt
In vitro studies of isolated skeletal muscle have shown that oxidative stress is limiting with respect to contractile function. Mitochondria are a potential source of muscle function-limiting oxidants. To test the hypothesis that skeletal muscle-specific mitochondrial oxidative stress is sufficient to limit muscle function, we bred mice expressing Cre recombinase driven by the promoter for the inhibitory subunit...
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