Article
Hypoxia Resistance Is an Inherent Phenotype of the Mouse Flexor Digitorum Brevis Skeletal Muscle.
Function (Oxford, England) - 1 Jan 2023
Amorese Adam J, Minchew Everett C, Tarpey Michael D, Readyoff Andrew T, Williamson Nicholas C, Schmidt Cameron A, McMillin Shawna L, Goldberg Emma J, Terwilliger Zoe S, Spangenburg Quincy A, Witczak Carol A, Brault Jeffrey J, Abel E Dale, McClung Joseph M, Fisher-Wellman Kelsey H, Spangenburg Espen E
Abstract excerpt
The various functions of skeletal muscle (movement, respiration, thermogenesis, etc.) require the presence of oxygen (O2). Inadequate O2 bioavailability (ie, hypoxia) is detrimental to muscle function and, in chronic cases, can result in muscle wasting. Current therapeutic interventions have proven largely ineffective to rescue skeletal muscle from hypoxic damage. However, our lab has identified a mammalian...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.