Article

SOD2 in Skeletal Muscle: New Insights from an Inducible Deletion Model

2021-05-21

Abstract excerpt

Metabolic conditions such as obesity, insulin resistance and glucose intolerance are frequently associated with impairments in skeletal muscle function and metabolism. This is often linked to dysregulation of homeostatic pathways including an increase in reactive oxygen species (ROS) and oxidative stress. One of the main sites of ROS production is the mitochondria, where the flux of substrates through the electron...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c1b1a8f5-31fa-55fc-9431-77ceb859a5be
DOI: 10.1101/2021.05.20.443346

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SOD2 in Skeletal Muscle: New Insights from an Inducible Deletion ModelDOI 10.1101/2021.05.20.443346Read

Antioxidants improve the phenotypes of dilated cardiomyopathy and muscle fatigue in mitochondrial superoxide dismutase-deficient mice.Semantic proximity Read

Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity.Semantic proximity Read

Mitochondrial superoxide radicals differentially affect muscle activity and neural function.Semantic proximity Read

Inducible and reversible SOD2 knockdown in mouse skeletal muscle drives impaired pyruvate oxidation and reduced metabolic flexibilitySemantic proximity Read

Sod2 overexpression preserves myoblast mitochondrial mass and function, but not muscle mass with aging.Semantic proximity Read

Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.Semantic proximity Read

Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo.Semantic proximity Read

Mitochondrial reactive oxygen species in mice lacking superoxide dismutase 2: attenuation via antioxidant treatment.Semantic proximity Read

Mitochondrial peptidase IMMP2L mutation causes early onset of age-associated disorders and impairs adult stem cell self-renewal.Semantic proximity Read

The Sod2 mutant mouse as a model for oxidative stress: a functional proteomics perspective.Semantic proximity Read

Redox Characterization of Functioning Skeletal MuscleSemantic proximity Read

Redox regulation by Pitx2 and Pitx3 is critical for fetal myogenesis.Semantic proximity Read