Article

Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis

2023-01-27

Abstract excerpt

<h4>Abstract/Summary</h4> Oncogenic RAS mutations drive aggressive cancers that are difficult to treat in the clinic, and while direct inhibition of the most common KRAS variant in lung adenocarcinoma (G12C) is undergoing clinical evaluation, a wide spectrum of oncogenic RAS variants together make up a large percentage of untargetable lung and GI cancers. Here we report that loss-of-function alterations (mutation...

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Literature Corpus work: eb2db7a4-a8fb-5e19-8117-a4033d89099c
DOI: 10.1101/2023.01.26.525772

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