Article
Combinatorial Inactivation of Tumor Suppressors Efficiently Initiates Lung Adenocarcinoma with Therapeutic Vulnerabilities.
Cancer research - 15 Apr 2022
Yousefi Maryam, Boross Gábor, Weiss Carly, Murray Christopher W, Hebert Jess D, Cai Hongchen, Ashkin Emily L, Karmakar Saswati, Andrejka Laura, Chen Leo, Wang Minwei, Tsai Min K, Lin Wen-Yang, Li Chuan, Yakhchalian Pegah, Colón Caterina I, Chew Su-Kit, Chu Pauline, Swanton Charles, Kunder Christian A, Petrov Dmitri A, Winslow Monte M
Abstract excerpt
Lung cancer is the leading cause of cancer death worldwide, with lung adenocarcinoma being the most common subtype. Many oncogenes and tumor suppressor genes are altered in this cancer type, and the discovery of oncogene mutations has led to the development of targeted therapies that have improved clinical outcomes. However, a large fraction of lung adenocarcinomas lacks mutations in known oncogenes, and the...
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