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Article

High PER1 expression is associated with STK11 mutation and clinical biomarkers of immunotherapy resistance in lung adenocarcinoma.

Journal of cancer research and clinical oncology - 26 Jul 2025

Parker Rebecca E, McSwain Leon, Zhou Wei, Marcus Adam I, Fu Haian, Ramalingam Suresh S, Zhang Shirley, Gilbert-Ross Melissa

Abstract excerpt

AIM: This study characterizes the functional effects and clinical characteristics of high PER1 mRNA and high PER1 protein expression in treatment resistant lung adenocarcinoma. METHODS: HBEC3-KT cells were modified by STK11 CRISPR knockout and A549 cells by LKB1 addback using stable transfection. RNA sequencing and western blot were used to profile gene and protein expression. Pooled siRNA knockdown of PER1 was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40715535
DOI: 10.1007/s00432-025-06269-9
PMCID: PMC12297223

Genes

PER1
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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