Article

Identification of a Clinically Relevant Signature for Early Progression in KRAS-Driven Lung Adenocarcinoma

2019-03-30

Abstract excerpt

Inducible genetically defined mouse models of cancer uniquely facilitate the investigation of early events in cancer progression, however there are valid concerns about the ability of such models to faithfully recapitulate human disease.  We developed an inducible mouse model of progressive lung adenocarcinoma (LuAd) that combines sporadic activation of oncogenic KRasG12D with modest overexpression of c-MYC (...

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Literature Corpus work: 847bbbb8-10d8-5418-9c92-5b5d999cb746
DOI: 10.20944/preprints201903.0286.v1

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