Article

Age and neuroinflammation are important components of the mechanism of cognitive and neurobehavioral deficits in sickle cell disease

2020-03-25

Abstract excerpt

<h4>Objectives</h4> Cognitive and neurobehavioral abnormalities are the most common and complex complications of sickle cell disease (SCD). Known risk factors influencing abnormalities are stroke and silent cerebral infarcts, but a majority of cases do not have overt cerebral injury and the underlying mechanism is not well understood. This study aims to determine whether sickle cell mice could recapitulate featur...

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Literature Corpus work: eb12ee09-2b82-55ca-8541-f5ce1707fd1a
DOI: 10.1101/2020.03.24.006221

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