Article

Frataxin deficiency in the astrocytes drives neurocognitive impairment in sickle cell disease mice

2024-12-21

Abstract excerpt

Individuals with sickle cell disease (SCD) suffer from a high burden of cerebrovascular lesions and cognitive impairment that vastly impact quality of life. Cerebrovascular lesions are characterized by microstructural neuroaxonal damage, but their pathogenesis has not been fully elucidated. Herein, we report that SCD mice (SS) have reduced expression of frataxin (FXN), a mitochondrial protein, in their astrocytes...

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Literature Corpus work: 7462a84a-dbd4-52d0-b200-97004e21326f
DOI: 10.1101/2024.12.20.629760

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