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Article

Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Nov 2013

Hagemann Tracy L, Paylor Richard, Messing Albee

Abstract excerpt

Glial fibrillary acidic protein (GFAP) is the major intermediate filament of mature astrocytes in the mammalian CNS. Dominant gain of function mutations in GFAP lead to the fatal neurodegenerative disorder, Alexander disease (AxD), which is characterized by cytoplasmic protein aggregates known as Rosenthal fibers along with variable degrees of leukodystrophy and intellectual disability. The mechanisms by which...

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Identifiers

PMID: 24259590
DOI: 10.1523/JNEUROSCI.3693-13.2013
PMCID: PMC3834063

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease.PMID 24259590Read ↗

Gfap Mutation and Astrocyte Dysfunction Lead to a Neurodegenerative Profile with Impaired Synaptic Plasticity and Cognitive Deficits in a Rat Model of Alexander Disease.Semantic proximity Read ↗

Synergistic Effects of Glial Fibrillary Acidic Protein Mutation and Overexpression in the Pathogenesis of Alexander Disease.Semantic proximity Read ↗

Alexander disease: models, mechanisms, and medicine.Semantic proximity Read ↗

Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease.Semantic proximity Read ↗

Pexidartinib treatment in Alexander disease model mice reduces macrophage numbers and increases glial fibrillary acidic protein levels, yet has minimal impact on other disease phenotypes.Semantic proximity Read ↗

GFAP mutations in Alexander disease.Semantic proximity Read ↗

The Noonan Syndrome-linked Raf1L613V mutation drives increased glial number in the mouse cortex and enhanced learningSemantic proximity Read ↗

Antisense therapy in a new rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairmentSemantic proximity Read ↗

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Antisense therapy in a rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.Semantic proximity Read ↗

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