Article

Imbalance in Redox Homeostasis is Associated with Neurodegeneration in the Murine Model of Tay-Sachs Disease

2024-10-30

Abstract excerpt

<title>Abstract</title> <p>Background Tay-Sachs disease is a type of neurodegenerative disorder with a build-up of GM2 ganglioside in the brain, which results in progressive central nervous system dysfunction. Our group recently generated <italic>Hexa-/-Neu3-/-</italic> mice, a murine model with neuropathological abnormalities similar to the infantile form of Tay-Sachs disease. Previously, we reported progressiv...

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Literature Corpus work: 7c37e151-3c51-5829-a94d-4ff2bdd5020a
DOI: 10.21203/rs.3.rs-5293300/v1

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