Article
Cognitive and behavior deficits in sickle cell mice are associated with profound neuropathologic changes in hippocampus and cerebellum.
Neurobiology of disease - 1 Jan 2016
Wang Li, Almeida Luis E F, de Souza Batista Celia M, Khaibullina Alfia, Xu Nuo, Albani Sarah, Guth Kira A, Seo Ji Sung, Quezado Martha, Quezado Zenaide M N
Abstract excerpt
Strokes are perhaps the most serious complications of sickle cell disease (SCD) and by the fifth decade occur in approximately 25% of patients. While most patients do not develop strokes, mounting evidence indicates that even without brain abnormalities on imaging studies, SCD patients can present profound neurocognitive dysfunction. We sought to evaluate the neurocognitive behavior profile of humanized SCD mice...
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