Article

Xylose phosphatase activity of dystroglycan self-regulates its receptor function

2025-10-11

Abstract excerpt

Dystroglycan (DG), a transmembrane receptor crucial for tissue development and pathogen entry, harbors a glycan composed of xylose and glucuronic acid called matriglycan. Loss of matriglycan or reduction in its length affects DG function, causing dystroglycanopathies. However, the mechanism underlying matriglycan extension is unknown. Here, we show that a Golgi xylose kinase facilitates initiation of matriglycan s...

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Literature Corpus work: eb0ac284-813f-5a49-8dfc-c85e8e625b38
DOI: 10.1101/2025.10.10.681626

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