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Article

Dystroglycan: from biosynthesis to pathogenesis of human disease

12 Jan 2006

Abstract excerpt

Alpha- and beta-dystroglycan constitute a membrane-spanning complex that connects the extracellular matrix to the cytoskeleton. Although a structural role for dystroglycan had been identified, biochemical and genetic discoveries have recently highlighted the significance of posttranslational processing for dystroglycan function. Glycosylation is the crucial modification that modulates the function of dystroglycan...

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Identifiers

PMID: 16410545
DOI: 10.1242/jcs.02814

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