Article

The homodimeric structure of the LARGE1 dual glycosyltransferase

2022-05-12

Abstract excerpt

LARGE1 is a bifunctional glycosyltransferase responsible for generating a long linear polysaccharide termed matriglycan that links the cytoskeleton and the extracellular matrix and is required for proper muscle function. This matriglycan polymer is made with an alternating pattern of xylose and glucuronic acid monomers. Mutations in the LARGE1 gene have been shown to cause life-threatening dystroglycanopathies thr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 98434ad1-8592-5785-927a-2450fba7d0ad
DOI: 10.1101/2022.05.11.491581

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The homodimeric structure of the LARGE1 dual glycosyltransferaseDOI 10.1101/2022.05.11.491581Read

Molecular basis of collagen galactosylation by GLT25D1.Semantic proximity Read

The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation.Semantic proximity Read

Structural insights into GlcNAc-1-phosphotransferase that directs lysosomal protein transportSemantic proximity Read

Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE.Semantic proximity Read

Structure and mechanism of the human TMEM260 O-mannosyltransferaseSemantic proximity Read

Muscular dystrophy-dystroglycanopathy in a family of Labrador retrievers with a LARGE1 mutation.Semantic proximity Read

In-silico structural analysis of E509K mutation in LARGE and T192M mutation in Alpha Dystroglycan in the inhibition of glycosylation of Alpha Dystroglycan by LARGE.Semantic proximity Read

Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy.Semantic proximity Read

Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane.Semantic proximity Read

Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2Semantic proximity Read

Xylose phosphatase activity of dystroglycan self-regulates its receptor functionSemantic proximity Read

Xylose phosphatase activity of dystroglycan self-regulates its receptor function.Semantic proximity Read