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Article

LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy.

Nature - 7 Nov 2013

Goddeeris Matthew M, Wu Biming, Venzke David, Yoshida-Moriguchi Takako, Saito Fumiaki, Matsumura Kiichiro, Moore Steven A, Campbell Kevin P

Abstract excerpt

The dense glycan coat that surrounds every cell is essential for cellular development and physiological function, and it is becoming appreciated that its composition is highly dynamic. Post-translational addition of the polysaccharide repeating unit [-3-xylose-α1,3-glucuronic acid-β1-]n by like-acetylglucosaminyltransferase (LARGE) is required for the glycoprotein dystroglycan to function as a receptor for...

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Identifiers

PMID: 24132234
DOI: 10.1038/nature12605
PMCID: PMC3891507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy.PMID 24132234Read ↗

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