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Article

Xylose phosphatase activity of dystroglycan self-regulates its receptor function.

Science (New York, N.Y.) - 13 Aug 2026

Chandel Ishita, Venzke David, Wollesen Bailey A, Yu Liping, Campbell Kevin P

Abstract excerpt

Dystroglycan (DG) is an extracellular matrix receptor crucial for tissue development and pathogen entry. DG harbors a long, complex glycan called matriglycan. Loss of matriglycan or reduction in its length disrupts DG function, causing dystroglycanopathies. However, the mechanism regulating matriglycan length is unknown. In this study, we found that a xylose kinase facilitated the initiation of matriglycan...

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Identifiers

PMID: 42594207
DOI: 10.1126/science.adz7427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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