Article

Structural insights into GlcNAc-1-phosphotransferase that directs lysosomal protein transport

2021-03-25

Abstract excerpt

GlcNAc-1-phosphotransferase (GNPT) catalyzes the initial step in the formation of the mannose-6-phosphate tag that labels ∼60 lysosomal proteins for transport. Mutations in GNPT cause lysosomal storage disorders such as mucolipidoses. However, the molecular mechanism of GNPT remains unclear. Mammalian GNPTs are α2β2γ2 hexamers in which the core catalytic α- and β-subunits are derived from GNPTAB. Here, we present...

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Literature Corpus work: 8dd055d4-6cf1-59ad-9e7a-414d48cea8c2
DOI: 10.1101/2021.03.25.436948

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