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Article

The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation.

eLife - 3 Oct 2014

Willer Tobias, Inamori Kei-Ichiro, Venzke David, Harvey Corinne, Morgensen Greg, Hara Yuji, Beltrán Valero de Bernabé Daniel, Yu Liping, Wright Kevin M, Campbell Kevin P

Abstract excerpt

Dystroglycan is a cell membrane receptor that organizes the basement membrane by binding ligands in the extracellular matrix. Proper glycosylation of the α-dystroglycan (α-DG) subunit is essential for these activities, and lack thereof results in neuromuscular disease. Currently, neither the glycan synthesis pathway nor the roles of many known or putative glycosyltransferases that are essential for this process...

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Identifiers

PMID: 25279699
DOI: 10.7554/eLife.03941
PMCID: PMC4227050

Genes

FKRP
FKTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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