Article
Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.
Science (New York, N.Y.) - 26 Apr 2013
Jae Lucas T, Raaben Matthijs, Riemersma Moniek, van Beusekom Ellen, Blomen Vincent A, Velds Arno, Kerkhoven Ron M, Carette Jan E, Topaloglu Haluk, Meinecke Peter, Wessels Marja W, Lefeber Dirk J, Whelan Sean P, van Bokhoven Hans, Brummelkamp Thijn R
Abstract excerpt
Glycosylated α-dystroglycan (α-DG) serves as cellular entry receptor for multiple pathogens, and defects in its glycosylation cause hereditary Walker-Warburg syndrome (WWS). At least eight proteins are critical to glycosylate α-DG, but many genes mutated in WWS remain unknown. To identify modifiers of α-DG, we performed a haploid screen for Lassa virus entry, a hemorrhagic fever virus causing thousands of deaths...
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