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Article

Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE.

Science (New York, N.Y.) - 6 Jan 2012

Inamori Kei-ichiro, Yoshida-Moriguchi Takako, Hara Yuji, Anderson Mary E, Yu Liping, Campbell Kevin P

Abstract excerpt

Posttranslational modification of alpha-dystroglycan (α-DG) by the like-acetylglucosaminyltransferase (LARGE) is required for it to function as an extracellular matrix (ECM) receptor. Mutations in the LARGE gene have been identified in congenital muscular dystrophy patients with brain abnormalities. However, the precise function of LARGE remains unclear. Here we found that LARGE could act as a bifunctional...

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Identifiers

PMID: 22223806
DOI: 10.1126/science.1214115
PMCID: PMC3702376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dystroglycan function requires xylosyl- and glucuronyltransferase activities of LARGE.PMID 22223806Read ↗

LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy.Semantic proximity Read ↗

Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane.Semantic proximity Read ↗

In-silico structural analysis of E509K mutation in LARGE and T192M mutation in Alpha Dystroglycan in the inhibition of glycosylation of Alpha Dystroglycan by LARGE.Semantic proximity Read ↗

The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation.Semantic proximity Read ↗

Investigating the functions of LARGE: lessons from mutant mice.Semantic proximity Read ↗

The homodimeric structure of the LARGE1 dual glycosyltransferaseSemantic proximity Read ↗

Mouse large can modify complex N- and mucin O-glycans on alpha-dystroglycan to induce laminin binding.Semantic proximity Read ↗

Xylose phosphatase activity of dystroglycan self-regulates its receptor function.Semantic proximity Read ↗

Localization and functional analysis of the LARGE family of glycosyltransferases: significance for muscular dystrophy.Semantic proximity Read ↗

Clinical, pathologic, and mutational spectrum of dystroglycanopathy caused by LARGE mutations.Semantic proximity Read ↗

The roles of dystroglycan in the nervous system: insights from animal models of muscular dystrophySemantic proximity Read ↗

AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.Semantic proximity Read ↗

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