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Article

Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage.

Scientific reports - 9 May 2016

Reesink Heidi L, Bonnevie Edward D, Liu Sherry, Shurer Carolyn R, Hollander Michael J, Bonassar Lawrence J, Nixon Alan J

Abstract excerpt

Lubricin is a mucinous, synovial fluid glycoprotein that enables near frictionless joint motion via adsorption to the surface of articular cartilage and its lubricating properties in solution. Extensive O-linked glycosylation within lubricin's mucin-rich domain is critical for its boundary lubricating function; however, it is unknown exactly how glycosylation facilitates cartilage lubrication. Here, we find that...

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Identifiers

PMID: 27157803
DOI: 10.1038/srep25463
PMCID: PMC4860590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Galectin-3 Binds to Lubricin and Reinforces the Lubricating Boundary Layer of Articular Cartilage.PMID 27157803Read ↗

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