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Article

hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms.

Heart rhythm - 1 May 2016

Puckerin Akil, Aromolaran Kelly A, Chang Donald D, Zukin R Suzanne, Colecraft Henry M, Boutjdir Mohamed, Aromolaran Ademuyiwa S

Abstract excerpt

BACKGROUND: The human ether-à-go-go-related gene (hERG 1a) potassium channel is critical for cardiac repolarization. hERG 1b, another variant subunit, co-assembles with hERG 1a, modulates channel biophysical properties and plays an important role in repolarization. Mutations of hERG 1a lead to type 2 long QT syndrome (LQT2), and increased risk for fatal arrhythmias. The functional consequences of these mutations...

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Identifiers

PMID: 26775140
DOI: 10.1016/j.hrthm.2016.01.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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