Article
Gating and assembly of heteromeric hERG1a/1b channels underlying I(Kr) in the heart.
Novartis Foundation symposium - 1 Jan 2005
Robertson Gail A, Jones Eugenia M C, Wang Jinling
Abstract excerpt
Until recently, ion channels generating cardiac IKr were thought to comprise four identical alpha subunits encoded by the ERG1a transcript. Despite studies identifying another transcript, ERG1b, failure to identify the corresponding protein in native tissue led to the conclusion that the ERG1b subunit is not a constituent of cardiac IKr channels. Interestingly, hERG1b subunits coexpressed in heterologous systems...
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